The Centers for Disease Control and Prevention released in mid-November its updated Antibiotic Resistance Threats in the United States (AR Threats Report) indicating that antibiotic-resistant bacteria and fungi cause more than 2.8 million infections and 35,000 deaths in the United States each year. That means, on average, someone in the United States gets an antibiotic-resistant infection every 11 seconds and every 15 minutes someone dies. When Clostridioides difficile, a bacterium, which is not typically resistant but can cause deadly diarrhea and is associated with antibiotic use, is added to these, the U.S. toll of all the threats in the report exceeds 3 million infections and 48,000 deaths.
Using data sources not previously available, the new report shows that there were nearly twice as many annual deaths from antibiotic-resistant infections as CDC originally reported in 2013. Since then, the new report shows, prevention efforts have reduced deaths from antibiotic-resistant infections by 18 percent overall and by nearly 30 percent in hospitals. Without continued vigilance, however, this progress may be challenged by the increasing burden of some infections.
CDC’s 2019 report thus establishes a new national baseline of infections and deaths from antibiotic-resistant germs. Moreover, the new report categorizes the top antibiotic-resistant threats based on level of concern to human health: urgent, serious, or concerning.
In recent years, there have been fewer infections from five of the germs previously listed as “serious.” Infections from the urgent threat “nightmare bacteria” carbapenem-resistant Enterobacteriaceae (CRE) have remained stable—a noteworthy accomplishment given how quickly and broadly this deadly germ spread across the United States in the early 2000s.
“The new AR Threats Report shows us that our collective efforts to stop the spread of germs and preventing infections is saving lives,” says Robert R. Redfield, M.D., director of the Centers for Disease Control and Prevention. “The 2013 report propelled the nation toward critical action and investments against antibiotic resistance. Today’s report demonstrates notable progress, yet the threat is still real. Each of us has an important role in combating it. Lives here in the United States and around the world depend on it.”
New in the 2019 report:
Antibiotic resistance: A continuing threat
Overall, there has been significant progress preventing infections and deaths from resistant germs typically associated with hospitals. Deaths from antibiotic-resistant infections in hospitals went down 28 percent from 2012 to 2017. Nevertheless, antibiotic-resistant germs often found in healthcare, including CRE and methicillin-resistant Staphylococcus aureus (MRSA), caused more than 85 percent of the total deaths calculated in the report.
CDC strategies—preventing spread of germs, preventing device- and procedure-related infections, implementing the Containment Strategy to stop spread of emerging threats, and improving antibiotic use in outpatient settings by five percent—have helped hospitals and public health departments combat the antibiotic-resistant threats across the nation. Further preventing infections, including getting ahead of sepsis, and stopping the spread of germs will save more lives.
Rapid detection and prevention strategies have helped protect people from two community-associated germs: drug-resistant Streptococcus pneumoniae and drug-resistant tuberculosis (TB). Vaccines have helped reduce infections from Streptococcus pneumoniae in many at-risk groups, and the drug-resistant TB cases in the United States remain stable due to effective TB control strategies.
However, CDC is concerned about antibiotic-resistant infections that are on the rise in the community:
Estimating the threat of antibiotic-resistant germs
CDC experts analyzed data from various CDC data systems to create the 2019 AR Threats Report. These data and new methodologies provide more precise, though still conservative, estimates of the human costs of antibiotic resistance.
For the first time, CDC used electronic health data from U.S. hospitals to measure the burden of antibiotic-resistant infections, including attributable mortality, for seven of the 18 germs listed. CDC researchers assessed all 18 threats according to seven factors associated with resistant infections: health impact, economic impact, how common the infection is, a 10-year projection of how common it could become, how easily it spreads, availability of effective antibiotics, and barriers to prevention. Because new methods have been used, the burden of some germs can be compared to the 2013 estimates while others cannot.
Through its AR Solutions Initiative, CDC will continue to take a comprehensive approach to antibiotic resistance:
See the full 2019 AR Threats Report: https://www.cdc.gov/DrugResistance/biggest-threats.html.